Phellinus linteus: Science Based Benefits of the Mesima Mushroom

Phellinus linteus[i] is a fungus that feeds on the wood of several types of trees, including mulberry, and produces a woody, perennial fruiting body shaped a bit like a large hoof. It grows wild across much of the world, and is an important part of traditional folk medicine in parts of Asia. Its common name in English is the descriptive “black hoof,” but English speakers are often more familiar with the scientific name, or with one of the Asian names. The mushroom is “sangwhang” in Korea, “sanghuang” in China, and “meshimakobu” in Japan (or “mesima” for short).

Curiously, there has been some debate as to whether the mushroom identified in the folk tradition actually is P. linteus, as opposed to one or more closely-related species that are difficult to tell apart. The lack of clarity adds an interesting dimension to the research currently being done as to the real medicinal properties of the fungus.

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Phellinus linteus Identification and Description

Cap: Hoof-shaped, asymmetrical, usually dark brown, but dries to black.

Gills: This species has pores, rather than gills. The pore surface is pale reddish or yellowish brown when fresh and brown when dried.

Stem: absent. The fruiting body grows shelf-like from its substrate.

Taste: Bitter or astringent[ii].

Edibility: Not toxic, but not palatable, either.

Habitat: Feeds on the trunks of several hardwoods.

P. linteus[iii] is a wood decomposer and fruits from the side of tree trunks. While it is best known for fruiting on white mulberry, it also makes use of the Chinese lacquer tree and of several species in both the oak and aspen genera. Because the fruiting body is woody in texture, it can’t be eaten alone. Traditionally, it was made into tea, but has a bitter taste. Tinctures and other extracts are also popular, but these extracts are often even more bitter than the fruiting body. Many people today prefer to take the mushroom as a dry powder that can be mixed in with food or put into capsules.

Phellinus linteus Benefits

P. linteus has a long history of use in folk medicine and in Traditional Chinese Medicine as a treatment for several conditions, including diarrhea and other gastroenteric problems, haemorrhage, and cancers[iv]. As is usually the case, scientific research focuses less on confirming or refuting the efficacy of traditional uses and more on investigating the biochemistry of the fungus with the goal of identifying substances that might someday be made into pharmaceuticals. However, P. linteus is also being used as alternative or supplemental medicine in some clinical contexts[v].

Possible benefits for P. linteus use suggested by research include[vi]:

  • Treatments for asthma and certain allergy symptoms
  • Diabetes management
  • Treatments for eczema and other forms of allergic dermatitis
  • Antiviral activity
  • Antimicrobial activity
  • Anti-inflammatory activity
  • Immunomodulatory activity
  • Antioxidant activity
  • Treatments for some colon cancers, including certain difficult to treat colon cancers.
  • Treatments for prostate cancer
  • Treatments for certain breast cancers
  • Treatments for pancreatic cancers
  • Protection against certain forms of liver damage
  • Protection against certain degenerative neurological conditions


A study showed that treatment with an ethanol extract of P. linteus reduced the inflammatory response of mice in whom asthma had been induced[vii]. Previously, the use of the mushroom in treating asthma had not been well investigated.


A hot-water extract of P. linteus lowered blood glucose levels in rats experimentally given diabetes but did not prevent the development of diabetes[viii]. In contrast, a polysaccharide isolated from P. lineus did prevent diabetes in mice with an autoimmune disease that otherwise causes diabetes[ix].


Polysaccharides isolated from P. linteus sensitized colon cancer cells so that a standard chemotherapy agent could kill the cancer at a much lower dose, thus minimizing harmful side-effects; non-cancerous colon cells were unharmed[x].

In both in vitro studies and in animal studies, a water extract of P. linteus killed human prostate cancer cells; in the animal studies, human cancer cells were injected into mice[xi]. In the mice, the mushroom extract could not prevent the growth of tumors but did slow it. One man with a difficult-to-treat form of prostate cancer experiences a sudden remission after consuming P. linteus[xii]. A single case is by no means proof, but it does suggest possibilities.

In one in vitro study, P. linteus showed itself able to interfere with the ability of human breast cancer cells to go through the steps necessary for successful metastasis and invasion[xiii].

There have been very few clinical studies in human patients yet, and the mushroom’s value as a treatment for cancer has not been proven, but there is reason for optimism.

Other Benefits

Phellinus linteus contains several polysaccharides that, in in vitro studies, alter a number of biomedical pathways suggesting real immunomodulatory activity[xiv] that could be part of the mushroom’s cancer-fighting potential[xv] and has also effectively treated mice experimentally given a form of allergy-induced eczema[xvi]. Anti-inflammatory properties studied in cell cultures also suggest extracts of the mushroom may be useful against certain types of allergy[xvii].

The mushroom can also do what the immune system alone cannot. An extract of the fruiting body was effective against several strains of antibiotic-resistant Staphylococcus aureus[xviii]. Another study tested a different extract’s effectiveness against cultures of a group of pathogenic microbes and found that the mushroom does have potential as an antimicrobial agent[xix].

A study involving cultures of rat cells suggested that P. Linteus may be able to help protect against liver damage[xx].Another study involving cultures of human cells suggested that the mushroom may also protect against certain types of brain degeneration.

Phellinus linteus Dosage

The vast majority of research on P. linteus has involved only cell cultures. Some involve animal models. Very few have involved human subjects. There is thus a lack of reliable information on dosing—but that does not mean that dosing can be ignored. Too much or too little might have poor effects or none at all. Users can follow the recommendations of traditional practitioners, since P. linteus does have a long history of medicinal use, but research results will still be useful to discover whether the traditional uses are optimal.

It is worth noting that multiple types of extracts and other P. linteus products exist, and they do not necessarily always have the same effect, since preparation method can alter the chemical properties of the product. It is important to discuss specific products, as well as dosing, with an experienced practitioner.

Phellinus linteus Side Effects and Toxicity

Despite being sometimes recommended as immune-system support, P. linteus use can exacerbate at least one autoimmune disease, specifically pemohigus[xxi]. Otherwise, short-term studies have shown no indication of toxicity, but there have been no studies of possible long-term problems[xxii]. Despite the well-documented history of extensive human use, it is possible that some negative effects exist. Caution is in order.


[i] Chen, W., Tan, H., Liu, Q., Zheng, X., Zhang, H., Liu, Y., Xu, L. (2019). A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus. Molecules. 24(10): 1888.

[ii] Phellinus linteus (Sang Hwang Mushroom): Benefits and Side Effects. Medical Herbals website. Retrieved on October 30, 2019.

[iii] Ibid.

[iv] Phellinus linteus, Mesima, Meshimakobu, Song-Gen, Sang-Hwang. Medicinal Mushrooms website. Retieved on October 30, 2019.

[v] Phellinus linteus. Memorial Sloan Kettering Cancer Center website retrieved on October 30, 2019.

[vi] Phellinus linteus (Sang Hwang Mushroom): Benefits and Side Effects. Medicinal Herbals website. Retrieved on October 30, 2019.

[vii] Yan, G. H., Choi, Y. H. (2014). Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-kB and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma. Immune Network. 14(2): 107–115.

[viii] Yamac, M., Zetinoglu, M., Senturk, H., Kartkaya K., Kanbak, G., Bayramogly, G., Oglakci, A., Van Griensven L.J.(2016). Effects of Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes), Polysaccharide Extract in        Streptozotocin-Induced Diabetic Rats. International Journal of Medicinal Mushrooms. 18(4).: 301–11.

[ix] Ibid

[x] Yu, T., Ganapathy, S., Shen, L., Peng, B., Kim, S. Makriyannis, A., Chen, C. (2018). A Lethal Synergy Induced by Phellinus linteus and Camptothecin11 in Colon Cancer Cells. Oncotarget. 9(5): 6308–6319.

[xi] Tsuji, T., Du, W., Nishioka, T., Chen, L., Yamamoto, D., Chen, C. Y. (2010). Phellinus linteus Extract Sensitizes   Advanced Prostate Cancer Cells to Apoptosis in Athymic Nude Mice. PloS One. 5(3).

[xii] Shibata, Y., Kurita, S., Okugi, H., Yamanaka, H. (2004). Dramatic Remission of Hormone Refractory Prostate Cancer Achieved with Extract of the Mushroom, Phellinus linteus. Urologia Internationalis. 73: 188–190.

[xiii] Sliva, D., Jedinak, A., Kawasaki, J., Harvey, K., Slivova, V. (2008). Phellinus linteus Suppresses Growth, Angionesis and Invasive Behavior of Breast Cancer Cells Through the Inhibition of AKT Signaling. British Journal of Cancer.   98(8): 1348–1356.

[xiv] Wu, S., Liaw, C., Pan, S., Yang, H. C., Ng, L. (2013). Phellinus linteus Polysaccharides and Their Immunomodulatory Properties in Human Monocytic Cells.. Journal of Functional Foods. 5(2): 679–688.

[xv] Sliva, D. (2010). Medicinal Mushroom Phillinus linteus as an Alternative Cancer Therapy (Review). Experimental and Therapeutic Medicine. 1(3).

[xvi] Hwang, J. S., Kwon, H., Kim, J., Rho, J. (2012). Immunomodulatory Effect of Water Soluable Extract Separated from Mycelium of Phellinus linteus on Experimental Atopic Dermatitis. BMC Complimentary and Alternative Medicine.   12(1): 159.

[xvii] Park, H. (2017). Antiallergenic and Anti-inflammatory Activity of Phellinus linteus Grown on Panax ginseng. Food          Science and Biotechnology. 26(2): 467–472.

[xviii] Hur, J.M, Yang, C.H., Han, S.H., Lee, S.H., You, Y.O., Park, J.C., Kim, K. J. (2004). Antibacterial Effect of Phellinus linteus Against Methicillin-Resistant Staphylococcus aureus. Fitoterapia. 75 (6): 603-5.

[xix]  Techaoei, S., Jarmkom, K., Eakwaropas, P., Khobjai, W. (2017). An Alternative Antimicrobial Approach to Fight Bacterial Pathogens from Phellinus linteus. International Journal of Bioengineering and Life Sciences. 11(5)

[xx] Huang, S., Wang, P., Kuo, P., Hung, H., Pan, T. (2018). Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus. Molecules. 23(7): 1705.

[xxi] Phellinus linteus. Memorial Sloan Kettering Cancer Center website retrieved on October 30, 2019.

[xxii] Chen, W., Tan, H., Liu, Q., Zheng, X., Zhang, H. Liu, Y., X., L. (2019). A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus. Molecules. 24(10): 1888.

2 thoughts on “Phellinus linteus: Science Based Benefits of the Mesima Mushroom”

  1. Hey there, thanks so much for this amazing resource! I am doing some research online and found a few mushrooms that seem like they could be very helpful for my condition but I have not been able to find them on the retail market. Is there a way to ask you questions directly other than in a post? Thanks again,

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