Sclerotium of ‘native bread’, Laccocephalum mylittae.
Polyporus mylittae Cooke & Massee
Polyporus mylittae Sacc.
Mylitta australis (anamorph)
Notihydnum australe (anamorph)
Native bread (Australian aboriginal)
Lei Wan (Chinese)
Laccocephalum mylittae is used in traditional Chinese medicine as an antihelminthic (Wang and Zhu, 1989). The sclerotium were eaten by aboriginals in Australia as a food source, hence the common name Native bread.
Chinese researchers isolated a polysaccharide they named S-4001, shown to be a (1→3)-β-D- glucan with some (1→6) linkages. Administration of S-4001 significantly increased anti-inflammatory activity in a variety of animal models. Reported experimental effects of S-4001 (all from Wang and Zhu, 1989):
– inhibitory action on leukocyte migration induced by intraperitoneal injection of carboxymethylcellulose (CMC) in rats
– significant increase of corticosterone in plasma, but with no increase in ascorbic acid content in the adrenals of rats
– increase in clearance of Congo red from mice blood
– potentiation of the immunohemolysis reaction in 615 mice (a mouse leukemia model)
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Orchard AE, May TW, Young T. 2003.
Fungi of Australia 2B.
CSIRO Publishing, Australian Biological Resources Study.
Google Books excerpt